Some old 2-(4-(Aryl)- thiazole-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-tethanoisoindole-1,3(2H)-dione derivatives: Synthesis, inhibition effects and molecular docking studies on Aldose reductase and α-Glycosidase
نویسندگان
چکیده
Utilizing the simple chromatic techniques, Aldose reductase (AR) was derived from sheep liver. In addition, α-glycosidase Saccharomyces cerevisiae used as enzyme. It determined interactions between compounds and enzymes. Molecular docking method to compare biological activity values of molecules against current study, inhibition effect synthetic isoindol-substitute thiazole derivatives (3a-f) on AR, enzymes studied. series, compound 3b (Ki: 9.70±4.72 M) showed a maximum inhibitory impact towards AR while 3f 44.40±17.18 lowest AR. investigated potent profiles with Ki in range 24.54±6.92–44.25±10.34 M α-glycosidase. Theoretical results were found consistent experimental results. Acting antidiabetic agents, these have potential be selective inhibitor The activities studied will compared molecular method. ADME analysis done.
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ژورنال
عنوان ژورنال: Cumhuriyet Science Journal
سال: 2021
ISSN: ['2587-2680', '2587-246X']
DOI: https://doi.org/10.17776/csj.897800